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Document type:
journal article 
Author(s):
Weidle, UH; Klostermann, S; Eggle, D; Krüger, A 
Title:
Interleukin 6/interleukin 6 receptor interaction and its role as a therapeutic target for treatment of cachexia and cancer. 
Abstract:
Interleukin 6 (IL6) mediates pleiotropic physiological functions through its interaction with the IL6 receptor (IL6R). Signal transduction can occur via cis- and trans-signaling. The role of IL6/IL6R interaction via autocrine and paracrine loops in tumor proliferation and progression is discussed. The potential role of IL6/IL6R interaction in different experimental systems and tumor entities is summarized while the focus is on inhibition of IL6 signaling with monoclonal antibodies directed again...    »
 
Journal title abbreviation:
Cancer Genomics Proteomics 
Year:
2010 
Journal volume:
Journal issue:
Pages contribution:
287-302 
Language:
eng 
Print-ISSN:
1109-6535 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung