Benutzer: Gast  Login
Dokumenttyp:
Konferenzbeitrag 
Autor(en):
Sayuri K. Hortsch, Andreas Kremling 
Titel:
Adjusting Noise in the Genetic Toggle Switch through Stochastic Circuit Design 
Abstract:
Bistable genetic circuits are important regulatory elements that can serve as biological switches. However, for a switch to function correctly, the noise inherent to the circuit needs to be taken into account, as it affects the robustness of the system. Using the example of a genetic toggle switch, we analyse the dependence of its intrinsic noise on the biochemical properties of the circuit. To that end, the circuit is described stochastically, and the variances of mRNA and protein fluctuations...    »
 
Stichworte:
genetic toggle switch bistability stochastic modeling noise translational bursts 
Kongress- / Buchtitel:
IFAC-PaperOnLine 
Kongress / Zusatzinformationen:
7th Conference on Foundation of Systems Biology in Engineering FOSBE 2018 
Verlag / Institution:
ELSEVIER 
Jahr:
2018 
Sprache:
en 
TUM Einrichtung:
Professur für Systembiotechnologie 
Eingabe:
25.06.2019