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Document type:
Konferenzbeitrag 
Author(s):
Sayuri K. Hortsch, Andreas Kremling 
Title:
Adjusting Noise in the Genetic Toggle Switch through Stochastic Circuit Design 
Abstract:
Bistable genetic circuits are important regulatory elements that can serve as biological switches. However, for a switch to function correctly, the noise inherent to the circuit needs to be taken into account, as it affects the robustness of the system. Using the example of a genetic toggle switch, we analyse the dependence of its intrinsic noise on the biochemical properties of the circuit. To that end, the circuit is described stochastically, and the variances of mRNA and protein fluctuations...    »
 
Keywords:
genetic toggle switch bistability stochastic modeling noise translational bursts 
Book / Congress title:
IFAC-PaperOnLine 
Congress (additional information):
7th Conference on Foundation of Systems Biology in Engineering FOSBE 2018 
Publisher:
ELSEVIER 
Year:
2018 
Language:
en 
TUM Institution:
Professur für Systembiotechnologie 
Ingested:
25.06.2019