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- Document type:
- Journal Article
- Author(s):
- Vogt, M; Kuhn, A; Wiese, J; Eicken, A; Hess, J; Vogel, M
- Title:
- Reduced contractile reserve of the systemic right ventricle under Dobutamine stress is associated with increased brain natriuretic peptide levels in patients with complete transposition after atrial repair.
- Abstract:
- AIMS: To compare B-type natriuretic peptide (BNP) levels with response of systemic right ventricular function to Dobutamine stress. METHODS AND RESULTS: Sixteen patients aged 25.6 +/- 3.7 years (eight each after Senning or Mustard repair of complete transposition) were studied. Transoesophageal imaging was performed in the catheterization laboratory under general anaesthesia before and at the end of a 10 min infusion of 5 microg/kg/min of Dobutamine. The BNP levels were measured at rest. Myocardial Doppler data were acquired before and at peak stress in a four-chamber view. The BNP (pg/mL) values of 67.3 +/- 47.5 (14-189) were elevated. There was no correlation between BNP and IVA, strain, or systolic and diastolic velocities at rest. Dobutamine stress led to a significant increase in IVA, s-velocity, and strain but no significant change in e-velocity. A correlation was found between increase in IVA under Dobutamine and BNP levels (r = 0.57, P < 0.02). CONCLUSION: Elevated BNP levels correlate with response of systolic right ventricular function assessed by IVA to Dobutamine stress.
- Journal title abbreviation:
- Eur J Echocardiogr
- Year:
- 2009
- Journal volume:
- 10
- Journal issue:
- 5
- Pages contribution:
- 691-4
- Language:
- eng
- Fulltext / DOI:
- doi:10.1093/ejechocard/jep047
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/19401301
- Print-ISSN:
- 1525-2167
- TUM Institution:
- Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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