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Document type:
journal article 
Author(s):
Lehmann, MH; Kastenmuller, W; Kandemir, JD; Brandt, F; Suezer, Y; Sutter, G 
Title:
Modified vaccinia virus ankara triggers chemotaxis of monocytes and early respiratory immigration of leukocytes by induction of CCL2 expression. 
Abstract:
Orthopoxviruses commonly enter into humans and animals via the respiratory tract. Herein, we show that immigration of leukocytes into the lung is triggered via intranasal infection of mice with modified vaccinia virus Ankara (MVA) and not with the vaccinia virus (VACV) Elstree, Wyeth, or Western Reserve (WR) strain. Immigrating cells were identified as monocytes, neutrophils, and CD4(+) lymphocytes by flow cytometry and could be detected 24 h and 48 h postinfection. Using an in vitro chemotaxis...    »
 
Journal title abbreviation:
J Virol 
Year:
2009 
Journal volume:
83 
Journal issue:
Pages contribution:
2540-52 
Language:
eng 
Print-ISSN:
0022-538X 
TUM Institution:
Institut für Virologie