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Document type:
journal article 
Author(s):
Levin, A; Hayouka, Z; Brack-Werner, R; Volsky, DJ; Friedler, A; Loyter, A 
Title:
Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration. 
Abstract:
Following fusion of the human immunodeficiency virus type-1 (HIV-1) with host cells' membrane and reverse transcription of the viral RNA, the resulted cDNA is integrated into the host genome by the viral integrase enzyme (IN). Quantitative estimations have revealed that only 1-2 copies are integrated per infected cell, although many copies of the viral RNA are reverse-transcribed. The molecular mechanism that restricts the integration degree has not, so far, been elucidated. Following integratio...    »
 
Journal title abbreviation:
Protein Eng Des Sel 
Year:
2009 
Journal volume:
22 
Journal issue:
12 
Pages contribution:
753-63 
Language:
eng 
Print-ISSN:
1741-0126 
TUM Institution:
Institut für Virologie