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Document type:
journal article 
Author(s):
Thiermann, H; Worek, F; Eyer, P; Eyer, F; Felgenhauer, N; Zilker, T 
Title:
Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. 
Abstract:
OBJECTIVE: The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity. METHODS: We measured the activity of cholinesterase in plasma and AChE in red blood cells (RBC) and related these data with neuromuscular transmission analysis (ulnar nerve stimulation). Concomitantly, p...    »
 
Journal title abbreviation:
Clin Toxicol (Phila) 
Year:
2009 
Journal volume:
47 
Journal issue:
Pages contribution:
807-13 
Language:
eng 
Print-ISSN:
1556-3650 
TUM Institution:
Toxikologische Abteilung