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Document type:
journal article 
Author(s):
Hoboth, C; Hoffmann, R; Eichner, A; Henke, C; Schmoldt, S; Imhof, A; Heesemann, J; Hogardt, M 
Title:
Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis. 
Abstract:
BACKGROUND: In patients with cystic fibrosis (CF), the emergence of hypermutable Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently adapted to the inflamed lungs of these patients. OBJECTIVE: To provide a detailed survey of adaptive changes in the physiology of P. aeruginosa during chronic lung infection in patients with CF. METHODS: We performed a comparative proteome and transcriptome analysis of sequential, isogenic isolates recovered over a period of 3...    »
 
Journal title abbreviation:
J Infect Dis 
Year:
2009 
Journal volume:
200 
Journal issue:
Pages contribution:
118-30 
Language:
eng 
Print-ISSN:
0022-1899 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene