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Document type:
journal article 
Author(s):
Aly, S; Mages, J; Reiling, N; Kalinke, U; Decker, T; Lang, R; Ehlers, S 
Title:
Mycobacteria-induced granuloma necrosis depends on IRF-1. 
Abstract:
In a mouse model of mycobacteria-induced immunopathology, wild-type C57BL/6 (WT), IL-18-knockout (KO) and IFN-alphabeta receptor-KO mice developed circumscript, centrally necrotizing granulomatous lesions in response to aerosol infection with M. avium, whereas mice deficient in the IFN-gamma receptor, STAT-1 or IRF-1 did not exhibit granuloma necrosis. Comparative, microarray-based gene expression analysis in the lungs of infected WT and IRF-1-KO mice identified a set of genes whose differential...    »
 
Journal title abbreviation:
J Cell Mol Med 
Year:
2009 
Journal volume:
13 
Journal issue:
8B 
Pages contribution:
2069-82 
Language:
eng 
Print-ISSN:
1582-1838 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene