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Document type:
journal article 
Author(s):
Vogt, S; Wexel, G; Tischer, T; Schillinger, U; Ueblacker, P; Wagner, B; Hensler, D; Wilisch, J; Geis, C; Wübbenhorst, D; Aigner, J; Gerg, M; Krüger, A; Salzmann, GM; Martinek, V; Anton, M; Plank, C; Imhoff, AB; Gansbacher, B 
Title:
The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects. 
Abstract:
Growth factors like BMP2 have been tested for osteochondral repair, but transfer methods used until now were insufficient. Therefore, the aim of this study was to analyse if stable BMP2 expression after retroviral vector (Bullet) transduction is able to regenerate osteochondral defects in rabbits. Fibrin clots colonized by control or BMP2-transduced chondrocytes were generated for in vitro experiments and implantation into standardized corresponding osteochondral defects (n=32) in the rabbit tro...    »
 
Journal title abbreviation:
Biomaterials 
Year:
2009 
Journal volume:
30 
Journal issue:
12 
Pages contribution:
2385-92 
Language:
eng 
Print-ISSN:
0142-9612 
TUM Institution:
die; r experimentelle Onkologie und Therapieforschung; dische Klinik und Poliklinik