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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article 
Author(s):
Schweizerhof, M; Stösser, S; Kurejova, M; Njoo, C; Gangadharan, V; Agarwal, N; Schmelz, M; Bali, KK; Michalski, CW; Brugger, S; Dickenson, A; Simone, DA; Kuner, R 
Title:
Hematopoietic colony-stimulating factors mediate tumor-nerve interactions and bone cancer pain. 
Abstract:
Pain is one of the most severe and debilitating symptoms associated with several forms of cancer. Various types of carcinomas and sarcomas metastasize to skeletal bones and cause spontaneous bone pain and hyperalgesia, which is accompanied by bone degradation and remodeling of peripheral nerves. Despite recent advances, the molecular mechanisms underlying the development and maintenance of cancer-evoked pain are not well understood. Several types of non-hematopoietic tumors secrete hematopoietic...    »
 
Journal title abbreviation:
Nat Med 
Year:
2009 
Journal volume:
15 
Journal issue:
Pages contribution:
802-7 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1078-8956 
TUM Institution:
Chirurgische Klinik und Poliklinik