Benutzer: Gast  Login
Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Esparza-Gordillo, J; Weidinger, S; Folster-Holst, R; Bauerfeind, A; Rüschendorf, F; Patone, G; Rohde, K; Marenholz, I; Schulz, F; Kerscher, T; Hübner, N; Wahn, U; Schreiber, S; Franke, A; Vogler, R; Heath, S; Baurecht, H; Novak, N; Rodriguez, E; Illig, T; Lee-Kirsch, MA; Ciechanowicz, A; Kurek, M; Piskackova, T; Macek, M; Lee, YA; Ruether, A
Titel:
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Abstract:
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined)...     »
Zeitschriftentitel:
Nat Genet
Jahr:
2009
Band / Volume:
41
Heft / Issue:
5
Seitenangaben Beitrag:
596-601
Sprache:
eng
Volltext / DOI:
doi:10.1038/ng.347
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19349984
Print-ISSN:
1061-4036
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
 BibTeX