A common variant on chromosome 11q13 is associated with atopic dermatitis.

Esparza-Gordillo, J; Weidinger, S; Folster-Holst, R; Bauerfeind, A; Rüschendorf, F; Patone, G; Rohde, K; Marenholz, I; Schulz, F; Kerscher, T; Hübner, N; Wahn, U; Schreiber, S; Franke, A; Vogler, R; Heath, S; Baurecht, H; Novak, N; Rodriguez, E; Illig, T; Lee-Kirsch, MA; Ciechanowicz, A; Kurek, M; Piskackova, T; Macek, M; Lee, YA; Ruether, A

doi:10.1038/ng.347

2009

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Document type:: Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Esparza-Gordillo, J; Weidinger, S; Folster-Holst, R; Bauerfeind, A; Rüschendorf, F; Patone, G; Rohde, K; Marenholz, I; Schulz, F; Kerscher, T; Hübner, N; Wahn, U; Schreiber, S; Franke, A; Vogler, R; Heath, S; Baurecht, H; Novak, N; Rodriguez, E; Illig, T; Lee-Kirsch, MA; Ciechanowicz, A; Kurek, M; Piskackova, T; Macek, M; Lee, YA; Ruether, A
Title:: A common variant on chromosome 11q13 is associated with atopic dermatitis.
Abstract:: We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers. «
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined)... »
Journal title abbreviation:: Nat Genet
Year:: 2009
Journal volume:: 41
Journal issue:: 5
Pages contribution:: 596-601
Language:: eng
Fulltext / DOI:: doi:10.1038/ng.347
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/19349984
Print-ISSN:: 1061-4036
TUM Institution:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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mediaTUM Gesamtbestand Hochschulbibliographie 2009 Fakultäten Medizin Molekulare Allergologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2009

mediaTUM Gesamtbestand Hochschulbibliographie 2009 Fakultäten Medizin Institut für Medizinische Statistik und Epidemiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Molekulare Allergologie (Prof. Schmidt-Weber)Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber)2009

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Dermatologie und Allergologie (Prof. Biedermann)2009