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Document type:
journal article 
Author(s):
Miederer, I; Ziegler, SI; Liedtke, C; Spilker, ME; Miederer, M; Sprenger, T; Wagner, KJ; Drzezga, A; Boecker, H 
Title:
Kinetic modelling of [11C]flumazenil using data-driven methods. 
Abstract:
PURPOSE: [(11)C]Flumazenil (FMZ) is a benzodiazepine receptor antagonist that binds reversibly to central-type gamma-aminobutyric acid (GABA-A) sites. A validated approach for analysis of [(11)C]FMZ is the invasive one-tissue (1T) compartmental model. However, it would be advantageous to analyse FMZ binding with whole-brain pixel-based methods that do not require a-priori hypotheses regarding preselected regions. Therefore, in this study we compared invasive and noninvasive data-driven methods (...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2009 
Journal volume:
36 
Journal issue:
Pages contribution:
659-70 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; Neurologische Klinik und Poliklinik; sthesiologie