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Document type:
journal article 
Author(s):
Vogler, M; Walczak, H; Stadel, D; Haas, TL; Genze, F; Jovanovic, M; Gschwend, JE; Simmet, T; Debatin, KM; Fulda, S 
Title:
Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. 
Abstract:
Resistance to apoptosis is a hallmark of pancreatic cancer, a leading cause of cancer deaths. Therefore, novel strategies are required to target apoptosis resistance. Here, we report that the combination of X-linked inhibitor of apoptosis (XIAP) inhibition and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an effective approach to trigger apoptosis despite Bcl-2 overexpression and to suppress pancreatic cancer growth in vitro and in vivo. Knockdown of XIAP by RNA interference...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2008 
Journal volume:
68 
Journal issue:
19 
Pages contribution:
7956-65 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Urologische Klinik und Poliklinik