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Document type:
journal article 
Author(s):
Bernhard, H; Neudorfer, J; Gebhard, K; Conrad, H; Hermann, C; Nährig, J; Fend, F; Weber, W; Busch, DH; Peschel, C 
Title:
Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer. 
Abstract:
The human epidermal growth factor receptor 2 (HER2) has been targeted as a breast cancer-associated antigen by immunotherapeutical approaches based on HER2-directed monoclonal antibodies and cancer vaccines. We describe the adoptive transfer of autologous HER2-specific T-lymphocyte clones to a patient with metastatic HER2-overexpressing breast cancer. The HLA/multimer-based monitoring of the transferred T lymphocytes revealed that the T cells rapidly disappeared from the peripheral blood. The im...    »
 
Journal title abbreviation:
Cancer Immunol Immunother 
Year:
2008 
Journal volume:
57 
Journal issue:
Pages contribution:
271-80 
Language:
eng 
Print-ISSN:
0340-7004 
TUM Institution:
III. Medizinische Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene; r Allgemeine Pathologie und pathologische Anatomie