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- Document type:
- Journal Article; Article
- Author(s):
- Sibbing, D; von Beckerath, O; Schömig, A; Kastrati, A; von Beckerath, N
- Title:
- Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary intervention.
- Abstract:
- This study assessed the effect of body mass index (BMI) on platelet aggregation after administration of a high loading dose of clopidogrel 600 mg. Blood samples of 402 patients before percutaneous coronary intervention were collected >or=2 hours after administration of clopidogrel 600 mg. Platelet aggregation was measured in response to adenosine diphosphate (ADP; 5 and 20 microM). Patients were categorized as normal weight (BMI <25 kg/m(2)) or overweight (BMI >or=25 kg/m(2)). ADP-induced platelet aggregation was significantly higher in overweight patients than in normal-weight patients (46.0 +/- 21.8% vs 38.2 +/- 19.3% for ADP 5 microM, p = 0.0007; 55.1 +/- 22.7% vs 45.2 +/- 21.7% for ADP 20 microM, p <0.0001). Multivariate analyses demonstrated high BMI as the only independent predictor for increased ADP-induced platelet aggregation (p
- Journal title abbreviation:
- Am J Cardiol
- Year:
- 2007
- Journal volume:
- 100
- Journal issue:
- 2
- Pages contribution:
- 203-5
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.amjcard.2007.02.081
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/17631070
- Print-ISSN:
- 0002-9149
- TUM Institution:
- I. Medizinische Klinik und Poliklinik (Kardiologie)
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