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Document type:
journal article 
Author(s):
Devarapu, S K; Lorenz, G; Kulkarni, O P; Anders, H-J; Mulay, S R 
Title:
Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis. 
Abstract:
Autoimmunity involves immune responses directed against self, which are a result of defective self/foreign distinction of the immune system, leading to proliferation of self-reactive lymphocytes, and is characterized by systemic, as well as tissue-specific, inflammation. Numerous mechanisms operate to ensure the immune tolerance to self-antigens. However, monogenetic defects or genetic variants that weaken immune tolerance render susceptibility to the loss of immune tolerance, which is further t...    »
 
Journal title abbreviation:
Int Rev Cell Mol Biol 
Year:
2017 
Journal volume:
332 
Pages contribution:
43-154 
Language:
eng 
Print-ISSN:
1937-6448 
TUM Institution:
Abteilung für Nephrologie