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- Document type:
- Journal Article
- Author(s):
- Schmoll, Sabrina; Heier, Eva-Carina; Böll, Regina; Zellner, Tobias; Romanek, Katrin; Eyer, Florian; Rabe, Christian; Geith, Stefanie
- Title:
- Independent validation of the Tanta University Risk Model for intensive care requirement in acutely poisoned adults.
- Abstract:
- OBJECTIVE: To independently validate the predictive value of the Tanta University Risk Model for intensive care requirement in unselected poisoned patients. METHOD: Retrospective chart review of 293 poisoned patients. The Tanta University Risk Model was calculated as follows: Tanta University Risk Model = -1.966*Glasgow Coma Scale - 0.329*oxygen saturation - 0.212*diastolic blood pressure + 0.27*respiratory rate - 0.33*standard bicarbonate. It was then compared to a composite endpoint indicating an intensive care unit requirement (death in hospital, vasopressors, need for intubation). RESULTS: Nineteen of 293 patients had a complicated clinical course as defined by meeting the primary endpoint definition. Receiver operating characteristic analysis revealed the area under the curve to be 0.79 (95% confidence interval 0.73-0.83). A positive Tanta University Risk Model was defined >-73.46. Fifteen out of 84 patients with a positive Tanta University Risk Model had a complicated course, while four of 209 patients with a negative Tanta University risk model had a complicated course (P<0.0001, Fisher's exact test). The negative predictive value of the Tanta University Risk Model was 0.98 (95% confidence interval 0.95-0.99), the sensitivity was 0.79 and that specificity was 0.75. CONCLUSION: Poisoned patients with a negative Tanta University Risk Model score are unlikely to need an intensive care unit level of care.
- Journal title abbreviation:
- Clin Toxicol (Phila)
- Year:
- 2023
- Journal volume:
- 61
- Journal issue:
- 4
- Pages contribution:
- 266-269
- Fulltext / DOI:
- doi:10.1080/15563650.2023.2188142
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/37129221
- Print-ISSN:
- 1556-3650
- TUM Institution:
- Abteilung für Toxikologie (Prof. Eyer)
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