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Document type:
journal article 
Author(s):
Karimzadeh, Hadi; Kiraithe, Muthamia M; Kosinska, Anna D; Glaser, Manuel; Fiedler, Melanie; Oberhardt, Valerie; Salimi Alizei, Elahe; Hofmann, Maike; Mok, Juk Yee; Nguyen, Melanie; van Esch, Wim J E; Budeus, Bettina; Grabowski, Jan; Homs, Maria; Olivero, Antonella; Keyvani, Hossein; Rodríguez-Frías, Francisco; Tabernero, David; Buti, Maria; Heinold, Andreas; Alavian, Seyed Moayed; Bauer, Tanja; Schulze Zur Wiesch, Julian; Raziorrouh, Bijan; Hoffmann, Daniel; Smedile, Antonina; Rizzetto, Mario; W...    »
 
Title:
Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8 T Cells. 
Abstract:
Virus-specific CD8 T cell response seems to play a significant role in the outcome of hepatitis delta virus (HDV) infection. However, the HDV-specific T cell epitope repertoire and mechanisms of CD8 T cell failure in HDV infection have been poorly characterized. We therefore aimed to characterize HDV-specific CD8 T cell epitopes and the impacts of viral mutations on immune escape. In this study, we predicted peptide epitopes binding the most frequent human leukocyte antigen (HLA) types and asses...    »
 
Journal title abbreviation:
J Virol 
Year:
2018 
Journal volume:
92 
Journal issue:
13 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-538X 
TUM Institution:
Institut für Virologie