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Document type:
journal article 
Author(s):
Ko, Chunkyu; Chakraborty, Anindita; Chou, Wen-Min; Hasreiter, Julia; Wettengel, Jochen M; Stadler, Daniela; Bester, Romina; Asen, Theresa; Zhang, Ke; Wisskirchen, Karin; McKeating, Jane A; Ryu, Wang-Shick; Protzer, Ulrike 
Title:
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. 
Abstract:
Several steps in the HBV life cycle remain obscure because of a lack of robust in vitro infection models. These steps include particle entry, formation and maintenance of covalently closed circular (ccc) DNA, kinetics of gene expression and viral transmission routes. This study aimed to investigate infection kinetics and cccDNA dynamics during long-term culture.We selected a highly permissive HepG2-NTCP-K7 cell clone engineered to express sodium taurocholate co-transporting polypeptide (NTCP) th...    »
 
Journal title abbreviation:
J Hepatol 
Year:
2018 
Journal volume:
69 
Journal issue:
Pages contribution:
1231-1241 
Language:
eng 
Print-ISSN:
0168-8278 
TUM Institution:
Institut für Virologie