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Document type:
Journal Article
Author(s):
Brand, Rosa Margareta; Diddens, Jolien; Friedrich, Verena; Pfaller, Monika; Radbruch, Helena; Hemmer, Bernhard; Steiger, Katja; Lehmann-Horn, Klaus
Title:
Siponimod Inhibits the Formation of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis.
Abstract:
BACKGROUND AND OBJECTIVES: To investigate whether the formation or retention of meningeal ectopic lymphoid tissue (mELT) can be inhibited by the sphingosine 1-phosphate receptor 1,5 modulator siponimod (BAF312) in a murine model of multiple sclerosis (MS). METHODS: A murine spontaneous chronic experimental autoimmune encephalomyelitis (EAE) model, featuring meningeal inflammatory infiltrates resembling those in MS, was used. To prevent or treat EAE, siponimod was administered daily starting eith...     »
Journal title abbreviation:
Neurol Neuroimmunol Neuroinflamm
Year:
2022
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1212/NXI.0000000000001117
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34911793
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Neurologie
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