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Document type:
journal article 
Author(s):
Molnos, Sophie; Baumbach, Clemens; Wahl, Simone; Müller-Nurasyid, Martina; Strauch, Konstantin; Wang-Sattler, Rui; Waldenberger, Melanie; Meitinger, Thomas; Adamski, Jerzy; Kastenmüller, Gabi; Suhre, Karsten; Peters, Annette; Grallert, Harald; Theis, Fabian J; Gieger, Christian 
Title:
pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms. 
Abstract:
Genome-wide association studies allow us to understand the genetics of complex diseases. Human metabolism provides information about the disease-causing mechanisms, so it is usual to investigate the associations between genetic variants and metabolite levels. However, only considering genetic variants and their effects on one trait ignores the possible interplay between different "omics" layers. Existing tools only consider single-nucleotide polymorphism (SNP)-SNP interactions, and no practical...    »
 
Journal title abbreviation:
BMC Bioinformatics 
Year:
2017 
Journal volume:
18 
Journal issue:
Pages contribution:
429 
Language:
eng 
TUM Institution:
Institut für Humangenetik