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Dokumenttyp:
journal article 
Autor(en):
Badieyan, Zohreh Sadat; Berezhanskyy, Taras; Utzinger, Maximilian; Aneja, Manish Kumar; Emrich, Daniela; Erben, Reinhold; Schüler, Christiane; Altpeter, Philipp; Ferizi, Mehrije; Hasenpusch, Günther; Rudolph, Carsten; Plank, Christian 
Titel:
Transcript-activated collagen matrix as sustained mRNA delivery system for bone regeneration. 
Abstract:
Transcript therapies using chemically modified messenger RNAs (cmRNAs) are emerging as safe and promising alternatives for gene and recombinant protein therapies. However, their applications have been limited due to transient translation and relatively low stability of cmRNAs compared to DNA. Here we show that vacuum-dried cmRNA-loaded collagen sponges, termed transcript activated matrices (TAMs), can serve as depots for sustained delivery of cmRNA. TAMs provide steady state protein production f...    »
 
Zeitschriftentitel:
J Control Release 
Jahr:
2016 
Band / Volume:
239 
Seitenangaben Beitrag:
137-48 
Sprache:
eng 
Print-ISSN:
0168-3659 
TUM Einrichtung:
Institut für experimentelle Onkologie und Therapieforschung