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Document type:
journal article 
Author(s):
Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud; Rummel, Andreas 
Title:
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency. 
Abstract:
The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. One peculiarity is an exposed hydrophobic loop in the toxin's cell binding domain HC, which is located between the ganglioside- and protein receptor-binding sites, and that is particularly pronounced in the serotypes BoNT/B, DC, and G sharing synaptotagmin as protein receptor. He...    »
 
Journal title abbreviation:
PLoS Pathog 
Year:
2018 
Journal volume:
14 
Journal issue:
Pages contribution:
e1007048 
Language:
eng 
Print-ISSN:
1553-7366 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie