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Document type:
journal article 
Author(s):
Garzorz-Stark, Natalie; Lauffer, Felix; Krause, Linda; Thomas, Jenny; Atenhan, Anne; Franz, Regina; Roenneberg, Sophie; Boehner, Alexander; Jargosch, Manja; Batra, Richa; Mueller, Nikola S; Haak, Stefan; Groß, Christina; Groß, Olaf; Traidl-Hoffmann, Claudia; Theis, Fabian J; Schmidt-Weber, Carsten B; Biedermann, Tilo; Eyerich, Stefanie; Eyerich, Kilian 
Title:
Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T17-deviated acute contact dermatitis in human subjects. 
Abstract:
A standardized human model to study early pathogenic events in patients with psoriasis is missing. Activation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly used mouse model of psoriasis.We sought to investigate the potential of a human imiquimod patch test model to resemble human psoriasis.Imiquimod (Aldara 5% cream; 3M Pharmaceuticals, St Paul, Minn) was applied twice a week to the backs of volunteers (n = 18), and development of skin lesions was m...    »
 
Journal title abbreviation:
J Allergy Clin Immunol 
Year:
2018 
Journal volume:
141 
Journal issue:
Pages contribution:
1320-1333.e11 
Language:
eng 
Print-ISSN:
0091-6749 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Institut für Molekulare Allergologie