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Document type:
Journal Article
Author(s):
Festag, Julia; Festag, Marvin M; Asen, Theresa; Wettengel, Jochen M; Mück-Häusl, Martin A; Abdulhaqq, Shaheed; Stahl-Hennig, Christiane; Sacha, Jonah B; Burwitz, Benjamin J; Protzer, Ulrike; Wisskirchen, Karin
Title:
Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures.
Abstract:
Adoptive T cell therapy using natural T cell receptor (TCR) redirection is a promising approach to fight solid cancers and viral infections in liver and other organs. However, clinical efficacy of such TCR+-T cells has been limited so far. One reason is that syngeneic preclinical models to evaluate safety and efficacy of TCR+-T cells are missing. We, therefore, developed an efficient viral vector strategy mediating expression of human major histocompatibility complex (MHC)-I in hepatocytes, whic...     »
Journal title abbreviation:
Hum Gene Ther
Year:
2023
Journal volume:
34
Journal issue:
23-24
Pages contribution:
1204-1218
Fulltext / DOI:
doi:10.1089/hum.2023.035
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37747811
Print-ISSN:
1043-0342
TUM Institution:
Institut für Virologie (Prof. Protzer)
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