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Document type:
Article; Early Access; Journal Article 
Author(s):
Hiltensperger, Michael; Beltrán, Eduardo; Kant, Ravi; Tyystjärvi, Sofia; Lepennetier, Gildas; Domínguez Moreno, Helena; Bauer, Isabel J; Grassmann, Simon; Jarosch, Sebastian; Schober, Kilian; Buchholz, Veit R; Kenet, Selin; Gasperi, Christiane; Öllinger, Rupert; Rad, Roland; Muschaweckh, Andreas; Sie, Christopher; Aly, Lilian; Knier, Benjamin; Garg, Garima; Afzali, Ali M; Gerdes, Lisa Ann; Kümpfel, Tania; Franzenburg, Sören; Kawakami, Naoto; Hemmer, Bernhard; Busch, Dirk H; Misgeld, Thomas; Dorn...    »
 
Title:
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. 
Abstract:
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or 'mixed' priming of helper T cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant of helper T cell-induced immunopathology in remote organs. By site-specific in vivo labeling of antigen-specific T cells in inguinal (i) or gut draining mesenteric (m) lymph nodes, we show th...    »
 
Journal title abbreviation:
Nat Immunol 
Year:
2021 
Journal volume:
22 
Journal issue:
Pages contribution:
880-892 
Print-ISSN:
1529-2908 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik