User: Guest  Login
Document type:
Article; Early Access; Journal Article 
Author(s):
Kowarik, M C; Astling, D; Lepennetier, G; Ritchie, A; Hemmer, B; Owens, G P; Bennett, Jeffrey L 
Title:
Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients. 
Abstract:
Natalizumab and fingolimod are effective multiple sclerosis (MS) therapies that disrupt lymphocyte migration but have differential effects on B cell maturation and trafficking. We investigated their effects on peripheral blood (PB) and cerebrospinal fluid (CSF) B cell repertoires using next-generation deep sequencing. Paired CSF and PB B cell subsets (naïve, CD27+ memory, and CD27-IgD- double-negative B cells and plasmablasts) were collected by applying flow cytometry at baseline and after 6 mon...    »
 
Journal title abbreviation:
Neurotherapeutics 
Year:
2021 
Journal volume:
18 
Journal issue:
Pages contribution:
364-377 
Print-ISSN:
1933-7213 
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik