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Document type:
Journal Article; 1 
Author(s):
Demir, Ihsan Ekin; Kujundzic, Kristina; Pfitzinger, Paulo L; Saricaoglu, Ömer Cemil; Teller, Steffen; Kehl, Timo; Reyes, Carmen Mota; Ertl, Linda S; Miao, Zhenhua; Schall, Thomas J; Tieftrunk, Elke; Haller, Bernhard; Diakopoulos, Kalliope Nina; Kurkowski, Magdalena U; Lesina, Marina; Krüger, Achim; Algül, Hana; Friess, Helmut; Ceyhan, Güralp O 
Title:
Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However, we hypothesized the opposite process, that precancerous pancreatic cells secrete chemokines that chemoattract Schwann cells (SC) of nerves and thus induce ready-to-use routes of dissemination in early carcinogenesis. Here we show a peculiar role for the chemokine CXCL12 secreted in early PDAC and for its receptors CXCR4/CXCR7 on SC in the...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2017 
Journal volume:
114 
Journal issue:
Pages contribution:
E85-E94 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0027-8424 
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung; Institut für Medizinische Statistik und Epidemiologie