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Document type:
Journal Article; Comment 
Author(s):
Diakopoulos, Kalliope N; Algül, Hana 
Title:
New wine into old wineskins: PGC-1α and NF-κB in obesity and acute pancreatitis. 
Abstract:
Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology, Pérez and Ruiz-Pérez et al connected obesity and pancreatitis for the first time, through the transcriptional regulator PPARγ coactivator 1α (PGC-1α). Obesity reduces pancreatic PGC-1α levels and potentiates not only oxidative but also IL-6-mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC-1α to the NF-κB subunit p65. Blockade of the IL-6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC-1α/p65/IL-6 signaling in obesity and acute pancreatitis. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 
Journal title abbreviation:
J Pathol 
Year:
2019 
Journal volume:
248 
Journal issue:
Pages contribution:
6-8 
Fulltext / DOI:
Print-ISSN:
0022-3417 
TUM Institution:
Lehrstuhl für Tumormetabolismus (Prof. Algül)