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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Sorby-Adams, A J; Schneider, W T; Goncalves, R P; Knolle, F; Morton, A J
Titel:
Measuring executive function in sheep (Ovis aries) using visual stimuli in a semi-automated operant system.
Abstract:
BACKGROUND: Cognitive impairment is a distinguishing feature of many neurodegenerative diseases. The intra-dimensional (ID) extra-dimensional (ED) attentional set shift task is part of a clinical battery of tests used to evaluate executive function in Huntington's and Alzheimer's disease patients. The IDED task, however, has not translated well to pre-clinical rodent models of neurological disease. NEW METHOD: The ability to perform executive tasks coupled with a long lifespan makes sheep (Ovis aries) an ideal species for modelling cognitive decline in progressive neurodegenerative conditions. We describe the methodology for testing the performance of sheep in the IDED task using a semi-automated system in which visual stimuli are presented as coloured letters on computer screens. RESULTS: During each stage of IDED testing, all sheep (n = 12) learned successfully to discriminate between different colours and letters. Sheep were quick to learn the rules of acquisition at each stage. They required significantly more trials to reach criterion (p < 0.05) and made more errors (p < 0.05) following stimulus reversal, with the exception of the ED shift (p > 0.05). COMPARISON WITH EXISTING METHOD(S): Previous research shows that sheep can perform IDED set shifting in a walk-through maze using solid objects with two changeable dimensions (colour and shape) as the stimuli. Presenting the stimuli on computer screens provides better validity, greater task flexibility and higher throughput than the walk-through maze. CONCLUSION: All sheep completed each stage of the task, with a range of abilities expected in an outbred population. The IDED task described is ideally suited as a quantifiable and clinically translatable measure of executive function in sheep.
Zeitschriftentitel:
J Neurosci Methods
Jahr:
2021
Band / Volume:
351
Volltext / DOI:
doi:10.1016/j.jneumeth.2020.109009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33340554
Print-ISSN:
0165-0270
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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