Steroid-resistant nephrotic syndrome (SRNS), together with the histomorphological correlate focal segmental glomerulosclerosis (FSGS), is a leading cause of end-stage renal disease (ESRD) in older children, adolescents, and adults. The disease spectrum is characterized by great genetic heterogeneity, but nongenetic causes are also observed in FSGS. The genetic basis of SRNS/FSGS in adolescents and adults is far from being completely understood. Reliable discrimination of the genetic causes of SRNS/FSGS is imperative, as there are already numerous clinical implications. The identification of new disease-causing alleles and genes will enhance our understanding of the underlying pathomechanisms. Using extensive genetic testing there is the possibility of finding the unresolved genetic basis for the recurrence of FSGS in patients without a genetic variant.     «

Steroid-resistant nephrotic syndrome (SRNS), together with the histomorphological correlate focal segmental glomerulosclerosis (FSGS), is a leading cause of end-stage renal disease (ESRD) in older children, adolescents, and adults. The disease spectrum is characterized by great genetic heterogeneity, but nongenetic causes are also observed in FSGS. The genetic basis of SRNS/FSGS in adolescents and adults is far from being completely understood. Reliable discrimination of the genetic causes of SR...     »