User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Harrison, Luke; Pfuhlmann, Katrin; Schriever, Sonja C; Pfluger, Paul T 
Title:
Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice. 
Abstract:
OBJECTIVE: Obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (RG) of astrocytes and microglia. Here, using two diet models or pharmacological treatment, we assessed the effects of mild and drastic weight loss on RG, in the context of high-fat diet (HFD) induced obesity. METHODS: We subjected HFD-induced obese (DIO) male C57BL/6J mice to a weight loss intervention with a switch to standard chow, calorie restriction (CR), or treatme...    »
 
Journal title abbreviation:
Mol Metab 
Year:
2019 
Journal volume:
24 
Pages contribution:
149-155 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)