User: Guest  Login
Document type:
Journal Article 
Author(s):
Berland, Chloé; Montalban, Enrica; Perrin, Elodie; Di Miceli, Mathieu; Nakamura, Yuko; Martinat, Maud; Sullivan, Mary; Davis, Xue S; Shenasa, Mohammad Ali; Martin, Claire; Tolu, Stefania; Marti, Fabio; Caille, Stephanie; Castel, Julien; Perez, Sylvie; Salinas, Casper Gravesen; Morel, Chloé; Hecksher-Sørensen, Jacob; Cador, Martine; Fioramonti, Xavier; Tschöp, Matthias H; Layé, Sophie; Venance, Laurent; Faure, Philippe; Hnasko, Thomas S; Small, Dana M; Gangarossa, Giuseppe; Luquet, Serge H 
Title:
Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. 
Abstract:
Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype 2 (DRD2...    »
 
Journal title abbreviation:
Cell Metab 
Year:
2020 
Journal volume:
31 
Journal issue:
Pages contribution:
773-790.e11 
Print-ISSN:
1550-4131 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)