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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Spiessberger, B; Bernhard, D; Herrmann, S; Feil, S; Werner, C; Luppa, PB; Hofmann, F 
Titel:
cGMP-dependent protein kinase II and aldosterone secretion. 
Abstract:
ACTH-stimulated aldosterone secretion can be inhibited by atrio-natriuretic peptide/cGMP. The mechanism behind this modulation has been reported to involve cGMP-dependent activation of phosphodiesterase 2 (PDE2) and hydrolysis of cAMP. Recently it was reported that activation of cGMP-dependent protein kinase II (cGKII) stimulated aldosterone secretion in rat zona glomerulosa cells. The zona glomerulosa of the murine adrenal cortex expresses cGKII and PDE2. We used mice with a homozygous inactiva...    »
 
Zeitschriftentitel:
FEBS J 
Jahr:
2009 
Band / Volume:
276 
Heft / Issue:
Seitenangaben Beitrag:
1007-13 
Sprache:
eng 
Print-ISSN:
1742-464X 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Institut für Pharmakologie und Toxikologie