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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Klenke, S; Tan, S; Hahn, S; Mann, K; Hauner, H; Manthey, I; Peters, J; Siffert, W; Frey, UH 
Title:
A functional GNAQ promoter haplotype is associated with altered Gq expression and with insulin resistance and obesity in women with polycystic ovary syndrome. 
Abstract:
The G-protein Gq, encoded by GNAQ, is involved in glucose metabolism. The GNAQ promoter harbours three polymorphisms. The TT(-695/-694)GC polymorphism was already shown to affect Gq transcription. Accordingly, we (i) characterized the GNAQ promoter polymorphisms G(-173)A and G(-168)A, (ii) investigated potential influences upon the TT(-695/-694)GC polymorphism and (iii) studied the associations with metabolic abnormalities in polycystic ovary syndrome (PCOS).Characterization of the polymorphisms...    »
 
Journal title abbreviation:
Pharmacogenet Genomics 
Year:
2010 
Journal volume:
20 
Journal issue:
Pages contribution:
476-84 
Language:
eng 
Print-ISSN:
1744-6872 
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin