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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Loschko, J; Schlitzer, A; Dudziak, D; Drexler, I; Sandholzer, N; Bourquin, C; Reindl, W; Krug, AB 
Title:
Antigen delivery to plasmacytoid dendritic cells via BST2 induces protective T cell-mediated immunity. 
Abstract:
Plasmacytoid dendritic cells (PDCs) are capable of presenting Ags to T cells in a tolerogenic or immunogenic manner depending on the formulation of the Ag and the mode of stimulation. It has not been investigated whether effective adaptive immune responses useful for vaccination can be induced by Ab-mediated Ag targeting to PDCs in vivo. In this study, we show that Ag delivered to murine PDCs via bone marrow stromal cell Ag 2 (BST2)/CD317 in combination with TLR agonists as adjuvants is specific...    »
 
Journal title abbreviation:
J Immunol 
Year:
2011 
Journal volume:
186 
Journal issue:
12 
Pages contribution:
6718-25 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie