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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Eitz Ferrer, P; Potthoff, S; Kirschnek, S; Gasteiger, G; Kastenmuller, W; Ludwig, H; Paschen, SA; Villunger, A; Sutter, G; Drexler, I; Häcker, G 
Title:
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-?-dependent induction of pro-apoptotic Noxa. 
Abstract:
Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure. An MVA mutant lacking F1L (MVA?F1L) induces apoptosis, indicating that MVA infection activates and F1L functions to inhibit the apoptotic pathway. In this study we investigated the events leading to apoptosis upon infection by MVA?F1L. Apoptosis...    »
 
Journal title abbreviation:
PLoS Pathog 
Year:
2011 
Journal volume:
Journal issue:
Pages contribution:
e1002083 
Language:
eng 
Print-ISSN:
1553-7366 
TUM Institution:
Institut für Virologie