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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Liesenfeld, O; Parvanova, I; Zerrahn, J; Han, SJ; Heinrich, F; Muñoz, M; Kaiser, F; Aebischer, T; Buch, T; Waisman, A; Reichmann, G; Utermöhlen, O; von Stebut, E; von Loewenich, FD; Bogdan, C; Specht, S; Saeftel, M; Hoerauf, A; Mota, MM; Könen-Waisman, S; Kaufmann, SH; Howard, JC 
Title:
The IFN-?-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. 
Abstract:
Clearance of infection with intracellular pathogens in mice involves interferon-regulated GTPases of the IRG protein family. Experiments with mice genetically deficient in members of this family such as Irgm1(LRG-47), Irgm3(IGTP), and Irgd(IRG-47) has revealed a critical role in microbial clearance, especially for Toxoplasma gondii. The in vivo role of another member of this family, Irga6 (IIGP, IIGP1) has been studied in less detail. We investigated the susceptibility of two independently gener...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2011 
Journal volume:
Journal issue:
Pages contribution:
e20568 
Language:
eng 
Print-ISSN:
1932-6203 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene