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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Herner, A; Sauliunaite, D; Michalski, CW; Erkan, M; De Oliveira, T; Abiatari, I; Kong, B; Esposito, I; Friess, H; Kleeff, J 
Title:
Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling. 
Abstract:
Glutamate has been implicated in tumorigenesis through activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR). However, the function of a glutamate-to-AMPAR signal in pancreatic ductal adenocarcinoma (PDAC) has remained elusive. We now show that glutamate-mediated AMPA receptor activation increases invasion and migration of pancreatic cancer cells via activation of the classical MAPK pathway. Glutamate levels were increased in pancreatic cancer accompanie...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2011 
Journal volume:
129 
Journal issue:
10 
Pages contribution:
2349-59 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0020-7136 
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie