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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Halama, N; Michel, S; Kloor, M; Zoernig, I; Benner, A; Spille, A; Pommerencke, T; von Knebel, DM; Folprecht, G; Luber, B; Feyen, N; Martens, UM; Beckhove, P; Gnjatic, S; Schirmacher, P; Herpel, E; Weitz, J; Grabe, N; Jaeger, D 
Title:
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy. 
Abstract:
Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer (CRC) by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human CRC. Specifically, high densities of TILs in the primary tumor are associated with good prognosis independent of other prognostic markers. However, the prognostic role of TILs in metastatic CRC lesions is unknown, as is their role in response or resistance to conventional chemothe...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2011 
Journal volume:
71 
Journal issue:
17 
Pages contribution:
5670-7 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie