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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Nawaz, Schanila; Sánchez, Paula; Schmitt, Sebastian; Snaidero, Nicolas; Mitkovski, Mi?o; Velte, Caroline; Brückner, Bastian R; Alexopoulos, Ioannis; Czopka, Tim; Jung, Sang Y; Rhee, Jeong S; Janshoff, Andreas; Witke, Walter; Schaap, Iwan A T; Lyons, David A; Simons, Mikael 
Title:
Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. 
Abstract:
During CNS development, oligodendrocytes wrap their plasma membrane around axons to generate multilamellar myelin sheaths. To drive growth at the leading edge of myelin at the interface with the axon, mechanical forces are necessary, but the underlying mechanisms are not known. Using an interdisciplinary approach that combines morphological, genetic, and biophysical analyses, we identified a key role for actin filament network turnover in myelin growth. At the onset of myelin biogenesis, F-actin...    »
 
Journal title abbreviation:
Dev Cell 
Year:
2015 
Journal volume:
34 
Journal issue:
Pages contribution:
139-51 
Language:
eng 
Print-ISSN:
1534-5807 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)