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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Wüstner, Stefanie; Mejías-Luque, Raquel; Koch, Maximilian F; Rath, Eva; Vieth, Michael; Sieber, Stephan A; Haller, Dirk; Gerhard, Markus 
Title:
Helicobacter pylori ?-glutamyltranspeptidase impairs T-lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression. 
Abstract:
Helicobacter pylori (H. pylori) is a human-specific pathogen that has evolved to cope with the immune response elicited against the infection. We previously reported that H. pylori ?-glutamyltranspeptidase (gGT) impairs T-lymphocyte proliferation and thus might act as immune regulatory factor. In this study, we analysed the underlying mechanism and its implications for H. pylori persistence. We found that H. pylori gGT compromised T-cell proliferation, activation and effector cytokine expression...    »
 
Journal title abbreviation:
Cell Microbiol 
Year:
2015 
Journal volume:
17 
Journal issue:
Pages contribution:
51-61 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1462-5814 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene