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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Niedzielska, Magdalena; Raffi, Faizal A M; Tel, Jurjen; Muench, Sandra; Jozefowski, Katrin; Alati, Nour; Lahl, Katharina; Mages, Jörg; Billmeier, Ulrike; Schiemann, Matthias; Appelt, Uwe K; Wirtz, Stefan; Sparwasser, Tim; Hochrein, Hubertus; Figdor, Carl G; Keyse, Stephen M; Lang, Roland 
Title:
Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-? Production. 
Abstract:
Plasmacytoid dendritic cells (pDCs) efficiently produce large amounts of type I IFN in response to TLR7 and TLR9 ligands, whereas conventional DCs (cDCs) predominantly secrete high levels of the cytokines IL-10 and IL-12. The molecular basis underlying this distinct phenotype is not well understood. In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis as selectively expressed in pDCs, but not cDCs. We confirmed the constitutive expression of Dusp9 at the protei...    »
 
Journal title abbreviation:
J Immunol 
Year:
2015 
Journal volume:
195 
Journal issue:
Pages contribution:
1753-62 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene