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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Alkner, Sara; Tang, Man-Hung Eric; Brueffer, Christian; Dahlgren, Malin; Chen, Yilun; Olsson, Eleonor; Winter, Christof; Baker, Sara; Ehinger, Anna; Rydén, Lisa; Saal, Lao H; Fernö, Mårten; Gruvberger-Saal, Sofia K 
Title:
Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing. 
Abstract:
By convention, a contralateral breast cancer (CBC) is treated as a new primary tumor, independent of the first cancer (BC1). Although there have been indications that the second tumor (BC2) sometimes may represent a metastatic spread of BC1, this has never been conclusively shown. We sought to apply next-generation sequencing to determine a "genetic barcode" for each tumor and reveal the clonal relationship of CBCs.Ten CBC patients with detailed clinical information and available fresh frozen tu...    »
 
Journal title abbreviation:
Breast Cancer Res 
Year:
2015 
Journal volume:
17 
Pages contribution:
102 
Language:
eng 
Print-ISSN:
1465-542X 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie