User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Broere, F; du Pré, MF; van Berkel, LA; Garssen, J; Schmidt-Weber, CB; Lambrecht, BN; Hendriks, RW; Nieuwenhuis, EE; Kraal, G; Samsom, JN 
Title:
Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4. 
Abstract:
Oral intake of protein leads to tolerance through the induction of regulatory T cells (Tr cells) in mesenteric lymph nodes (MLNs). Here we show that the inhibition of cyclooxygenase-2 (COX-2) in vivo suppressed oral tolerance and was associated with enhanced differentiation of interleukin (IL)-4-producing T cells and reduced Foxp3(+) Tr-cell differentiation in MLN. As a result, the functional suppressive capacity of these differentiated mucosal T cells was lost. IL-4 was causally related to loss...    »
 
Journal title abbreviation:
Mucosal Immunol 
Year:
2009 
Journal volume:
Journal issue:
Pages contribution:
254-64 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1933-0219 
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)