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Document type:
journal article 
Author(s):
Wang, Baocai; Kaufmann, Benedikt; Engleitner, Thomas; Lu, Miao; Mogler, Carolin; Olsavszky, Victor; Öllinger, Rupert; Zhong, Suyang; Geraud, Cyrill; Cheng, Zhangjun; Rad, Roland R; Schmid, Roland M; Friess, Helmut; Hüser, Norbert; Hartmann, Daniel; von Figura, Guido 
Title:
Brg1 promotes liver regeneration after partial hepatectomy via regulation of cell cycle. 
Abstract:
Brahma-related gene 1 (Brg1), a catalytic subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex, is known to be involved in proliferative cell processes. Liver regeneration is initiated spontaneously after injury and leads to a strong proliferative response. In this study, a hepatocyte-specific Brg1 gene knockout mouse model was used to analyse the role of Brg1 in liver regeneration by performing a 70% partial hepatectomy (PH). After PH, Brg1 was significantly upregulated in wildtype m...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2019 
Journal volume:
Journal issue:
Pages contribution:
2320 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie