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Document type:
Zeitschriftenaufsatz 
Author(s):
Corrochano, Silvia; Blanco, Gonzalo; Williams, Debbie; Wettstein, Jessica; Simon, Michelle; Kumar, Saumya; Moir, Lee; Agnew, Thomas; Stewart, Michelle; Landman, Allison; Kotiadis, Vassilios N; Duchen, Michael R; Wackerhage, Henning; Rubinsztein, David C; Brown, Steve D M; Acevedo-Arozena, Abraham 
Title:
A genetic modifier suggests that endurance exercise exacerbates Huntington's disease 
Abstract:
Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine tract explain up to 70% of the age-at-onset variance, with the rest of the variance attributed to genetic and environmental modifiers. To identify novel disease modifiers, we performed an unbiased mutagenesis screen on an HD mouse model, identifying a mutation in the skel...    »
 
Keywords:
Huntington's disease 
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit; 790 Sport, Spiele, Unterhaltung 
Journal title:
Human Molecular Genetics 
Year:
2018 
Journal volume:
27 
Year / month:
2018-03 
Quarter:
1. Quartal 
Month:
Mar 
Journal issue:
10 
Pages contribution:
1723-1731 
Reviewed:
ja 
Language:
en 
Fulltext / DOI:
Publisher:
Oxford University Press (OUP) 
E-ISSN:
0964-69061460-2083 
Impact Factor:
4,9 
Date of publication:
02.03.2018 
Semester:
SS 19 
TUM Institution:
Sportbiologie