User: Guest  Login
Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review 
Author(s):
Brandt, Sara J; Götz, Anna; Tschöp, Matthias H; Müller, Timo D 
Title:
Gut hormone polyagonists for the treatment of type 2 diabetes. 
Abstract:
Chemical derivatives of the gut-derived peptide hormone glucagon-like peptide 1 (GLP-1) are among the best-in-class pharmacotherapies to treat obesity and type 2 diabetes. However, GLP-1 analogs have modest weight lowering capacity, in the range of 5-10%, and the therapeutic window is hampered by dose-dependent side effects. Over the last few years, a new concept has emerged: combining the beneficial effects of several key metabolic hormones into a single molecular entity. Several unimolecular G...    »
 
Journal title abbreviation:
Peptides 
Year:
2018 
Journal volume:
100 
Pages contribution:
190-201 
Print-ISSN:
0196-9781 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)